Cancer - Prostate Cancer, Breast Cancer, Lung Cancer

What is taxane?

A drug that inhibits cell growth by stopping cell division. Taxanes are used to treat breast cancer, lung cancer, and Prostate Cancer, and may be used for other cancers as well. Also called antimitotic or antimicrotubule agents or mitotic inhibitors.

Docetaxel and paclitaxel are taxanes.

Alerts

What are the possible side effects of docetaxel
If you experience any of the following serious side effects from docetaxel, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; or fever, chills, or signs of infection);

tissue or vein reactions near the site of administration;

liver damage (abdominal pain, yellowing of the skin or eyes);

severe nausea, vomiting, diarrhea, or loss of appetite;

swelling of the feet, ankles or abdomen;

difficulty breathing;

skin redness or peeling;

fever, chills, or other signs of infection; or

nerve problems such as burning, pricking or tingling.
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Side Effects

Nausea/Vomiting. Diarrhea

Hair Loss or thinning (usually temporary)

Bone marrow depression (increased risk for infection, fatigue, and bleeding)

Mouth/Throat soreness

Phlebitis (redness and tenderness of a vein)

Skin and nail changes

Edema, (swelling) usually in your ankles and feet

Irregular periods; cessation of menstruation

Vaginal dryness, itching

Decreased fertility (men and women)

Allergic reaction (rare) - shortness of breath, rash or itching, dizziness or lightheadedness, or palpitations.
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Warning
As well as killing cancer cells, docetaxel also affects normal, healthy cells, particularly those that multiply quickly such as blood cells. The most important side effect is on the bone marrow where blood cells are made. Docetaxel can decrease the production of blood cells, leaving people susceptible to infection. Regular blood tests are therefore needed to monitor levels of blood cells.
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